Glyburide
Overdosage of sulfonylureas, including glyburide tablets, can produce hypoglycemia.
Mild hypoglycemic symptoms, without loss of consciousness or neurological
findings, should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns.
Close monitoring should continue until the physician is assured that the patient
is out of danger. Severe hypoglycemic reactions with coma, seizure, or other
neurological impairment occur infrequently, but constitute medical emergencies
requiring immediate hospitalization. If hypoglycemic coma is diagnosed or
suspected, the patient should be given a rapid intravenous injection of concentrated (50%)
glucose solution. This should be followed by a continuous infusion of a more
dilute (10%) glucose solution at a rate that will maintain the blood glucose
at a level above 100 mg/dL. Patients should be closely monitored for a minimum
of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery.
Metformin Hydrochloride
Overdose of metformin hydrochloride has occurred, including ingestion of amounts
greater than 50 grams. Hypoglycemia was reported in approximately 10% of cases,
but no causal association with metformin hydrochloride has been established.
Lactic acidosis has been reported in approximately 32% of metformin overdose
cases (see WARNINGS). Metformin is dialyzable with a clearance of up to 170
mL/min under good hemodynamic conditions. Therefore, hemodialysis may be useful
for removal of accumulated drug from patients in whom metformin overdosage is suspected.
Glucovance
Pregnancy
Metabolism and elimination
Patients with type 2 diabetes
Hypoglycemia
Mechanism of action
Metformin hydrochloride
Information for patients
Drug interactions
Overdosage
Glipizide (glucotrol)
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