GLUCOVANCE is capable of producing hypoglycemia or hypoglycemic symptoms,
therefore, proper patient selection, dosing, and instructions are important
to avoid potential hypoglycemic episodes. The risk of hypoglycemia is increased
when caloric intake is deficient, when strenuous exercise is not compensated
by caloric supplementation, or during concomitant use with other glucose-lowering agents
or ethanol. Renal or hepatic insufficiency may cause elevated drug levels of
both glyburide and metformin hydrochloride and the hepatic insufficiency may
also diminish gluconeogenic capacity, both of which increase the risk of hypoglycemic reactions. Elderly, debilitated,
or malnourished patients and
those with adrenal or pituitary insufficiency or alcohol intoxication are particularly
susceptible to hypoglycemic effects. Hypoglycemia may be difficult to recognize
in the elderly, and in people who are taking beta-adrenergic blocking drugs.
Glucovance
Pregnancy
Metabolism and elimination
Patients with type 2 diabetes
Hypoglycemia
Mechanism of action
Metformin hydrochloride
Information for patients
Drug interactions
Overdosage
Glipizide (glucotrol)
Drugs without prescription
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