Certain drugs tend to produce hyperglycemia and may lead to loss of blood
glucose control. These drugs include the thiazides and other diuretics, corticosteroids,
phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin,
nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.
When such drugs are administered to a patient receiving GLUCOVANCE, the patient
should be closely observed for loss of blood glucose control. When such drugs
are withdrawn from a patient receiving GLUCOVANCE, the patient should be observed
closely for hypoglycemia. Metformin is negligibly bound to plasma proteins and is, therefore, less likely
to interact with highly
protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and
probenecid as compared to sulfonylureas, which are extensively bound to serum proteins.
Glyburide
The hypoglycemic action of sulfonylureas may be potentiated by certain drugs
including nonsteroidal anti-inflammatory agents and other drugs that are highly
protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins,
monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such
drugs are administered to a patient receiving GLUCOVANCE, the patient should be
observed closely for hypoglycemia. When such drugs are withdrawn from a patient
receiving GLUCOVANCE, the patient should be observed closely for loss of blood
glucose control. A possible interaction between glyburide and ciprofloxacin,
a fluoroquinolone antibiotic, has been
reported, resulting in a potentiation of the hypoglycemic action of glyburide.
The mechanism for this interaction is not known.
A potential interaction between oral miconazole and oral hypoglycemic agents
leading to severe hypoglycemia has been reported. Whether this interaction
also occurs with the intravenous, topical, or vaginal preparations of miconazole
is not known.
Glucovance
Pregnancy
Metabolism and elimination
Patients with type 2 diabetes
Hypoglycemia
Mechanism of action
Metformin hydrochloride
Information for patients
Drug interactions
Overdosage
Glipizide (glucotrol)
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